[0] Clinical Epidemiology - How to Do Clinical Practice Research (3rd ed. 2006) Haynes, Sackett, Guyatt(1).pdf - Haynes - palmoff

C LINICAL E PIDEMIOLOGY

H OW TO D O C LINICAL

P RACTICE R ESEARCH

Clinical Epidemiology: How to Do Clinical Practice Research .

C LINICAL E PIDEMIOLOGY

H OW TO D O C LINICAL

P RACTICE R ESEARCH

Third Edition

R. Brian Haynes, MD, PhD, FRCPC, FACP, FACMI

Professor of Clinical Epidemiology and Medicine

Michael G. DeGroote School of Medicine

Faculty of Health Sciences

McMaster University

Hamilton, Ontario, Canada

David L. Sackett, OC, MD, FRSC, FRCP (Canada, London, Edinburgh)

Director, Kilgore S. Trout Research & Education Centre

at Irish Lake, Canada

Gordon H. Guyatt, MD, MSc, FRCPC, FACP, FACCP

Professor of Clinical Epidemiology and Medicine

Michael G. DeGroote School of Medicine

Faculty of Health Sciences

McMaster University

Hamilton, Ontario, Canada

Peter Tugwell, MD, MSc, FRCPC

Professor of Medicine, and Epidemiology and Community Medicine

University of Ottawa

Ottawa, Ontario, Canada

Clinical Epidemiology: How to Do Clinical Practice Research .

Acquisitions Editor: Sonya Seigafuse

Managing Editor: Kerry Barrett

Project Manager: Nicole Walz

Senior Manufacturing Manager: Ben Rivera

Senior Marketing Manager: Kathy Neely

Creative Director: Doug Smock

Cover Designer: Louis Fuiano

Production Services: Laserwords Private Limited

Printer: Edwards Brothers

3rd Edition

reproduced in any form or by any means, including photocopying, or utilizing by any

information storage and retrieval system without written permission from the copyright owner,

except for brief quotations embodied in critical articles and reviews.

Printed in the United States

Clinical epidemiology: how to do clinical practice research / R. Brian Haynes … [et al.].— 3rd ed.

p. ; cm.

Includes bibliographical references.

ISBN 0-7817-4524-1

1. Clinical epidemiology. 2. Medicine—Research—Epidemiology. I. Haynes, R. Brian.

[DNLM: 1. Biomedical Research—methods. 2. Epidemiologic Methods. 3. Research Design.

WA 950 C6413 2005]

RA652.C45 2005

614.4—dc22

2005008293

Care has been taken to confirm the accuracy of the information presented and to describe

generally accepted practices. However, the authors, editors, and publisher are not responsible

for errors or omissions or for any consequences from application of the information in this

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or accuracy of the contents of the publication. Application of this information in a particular

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and dosage set forth in this text are in accordance with current recommendations and practice

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recommended agent is a new or infrequently employed drug.

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Administration (FDA) clearance for limited use in restricted research settings. It is the

responsibility of health care providers to ascertain the FDA status of each drug or device

planned for use in their clinical practice.

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Clinical Epidemiology: How to Do Clinical Practice Research .

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