Xiao-Ming Yin, Zheng Dong - Essentials of Apoptosis A Guide for Basic and Clinical Research - Humana 2009.pdf

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Essentials of Apoptosis: A Guide for Basic and Clinical Research
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Essentials of Apoptosis
Second Edition
Xiao-Ming Yin l Zheng Dong
Editors
Essentials of Apoptosis
A Guide for Basic and Clinical Research
Second Edition
13
 
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Editors
Xiao-Ming Yin
Department of Pathology
University of Pittsburgh
3500 Terrace Street
Pittsburgh PA 15261
Scaife Hall, 7th Floor
USA
xmyin@pitt.edu
Zheng Dong
Department of Graduate Studies
Medical College of Georgia
1459 Laney Walker Blvd.
Augusta GA 30912
USA
zdong@mcg.edu
DOI 10.1007/978-1-60327-381-7
e-ISBN 978-1-60327-381-7
Library of Congress Control Number: 2009921154
# Humana Press, a part of Springer Science þ Business Media, LLC 2009
All rights reserved. This workmay not be translated or copied in whole or in part without the written
permission of the publisher (Humana Press, c/o Springer Science þ BusinessMedia, LLC, 233 Spring
Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or
scholarly analysis. Use in connection with any form of information storage and retrieval,
electronic adaptation, computer software, or by similar or dissimilar methodology now known or
hereafter developed is forbidden.
The use in this publication of trade names, trademarks, service marks, and similar terms, even if they
are not identified as such, is not to be taken as an expression of opinion as to whether or not they are
subject to proprietary rights.
Printed on acid-free paper
springer.com
ISBN 978-1-60327-380-0
Preface to Second Edition
The first edition of this book was published in 2003. It was intended to provide
the basic and essential information of apoptosis for those who were new to the
field and who wanted to apply the knowledge to their own research. The book
therefore focused on the concepts, the basic molecular architecture, and the
pathophysiological significance of apoptosis. Since the first edition, there have
been tremendous new developments in the field of apoptosis and cell death in
general. The concept of various types of cell death has been further developed.
The studies in both basic and clinical disciplines have been greatly expanded.
In particular, notable progress has been made in extending the work into the
therapeutic arena. As a result, the field has matured considerably and developed
extensive cross-talk with works in other fields.
We strive to incorporate and reflect these new developments in the second
edition of this book. Our goal is to provide readers with the most updated
and advanced knowledge in the field, while maintaining the fundamental
information as presented in the first edition. To this end, the book has been
significant expanded, not only in the page and chapter numbers but more
importantly in the depth of coverage. Most of the chapters have been revised
and/or rewritten, and 15 new chapters have been added to give rise to a total of
31 chapters. In Part I, in addition to the discussion of the major apoptosis
molecules, the activation and regulatory pathways, and the clearance of
apoptotic cells, we also present important issues that examine apoptosis from
more integrated points of view. Thus, the roles of reactive oxygen species,
metabolism, and transcription control in apoptosis activation and regulation
are explored. A new systems biology approach to studying apoptosis is also
introduced. In Part II, we discuss apoptosis and cell death in four model
systems, including plant, yeast, C. elegans, and Drosophila, which together have
contributed greatly to our current understanding of cell death. In Part III, we focus
on mammalian cell death under various pathophysiological situations in all major
systems, including the hematopoietic and immune system, the brain, the heart, the
liver, the lung, and the kidney. Two integrated chapters discussing cell death in
normal development and in cancer biology have also been included. Furthermore,
a separate Part IV has been added to discuss the alternative mechanisms and
pathways of cell death. Finally, Part V discusses the technical aspect of apoptosis
v

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