Principles of Molecular Medicine - J. Jameson (Humana, 1998) WW.pdf - Bio Med 22 - Aivree

M OLECULAR

M EDICINE

EDITED BY

J. Larry Jameson

SECTION EDITORS

Joseph B. Martin

Michael J. McPhaul

Charles B. Nemeroff

James C. Reynolds

Anthony Rosenzweig

Swee Lay Thein

Ralph C. Williams, Jr.

HUMANA PRESS

P RINCIPLES OF

Dennis Ausiello

Andrea Ballabio

Michael J. Holtzman

Ethylin Wang Jabs

Laurence Kedes

Thomas Kupper

CONTENTS

P RINCIPLES OF M OLECULAR M EDICINE

CONTENTS

S ECTION E DITORS

D ENNIS A USIELLO , MD

D EPARTMENT OF M EDICINE

M ASSACHUSETTS G ENERAL H OSPITAL

B OSTON , MA

M ICHAEL J. M C P HAUL , MD

D EPARTMENT OF I NTERNAL M EDICINE

U NIVERSITY OF T EXAS

S OUTHWESTERN M EDICAL C ENTER

D ALLAS , TX

A NDREA B ALLABIO , MD

T ELETHON I NSTITUTE OF G ENETICS

AND M EDICINE

(T IGEM )

M ILANO , I TALY

C HARLES B. N EMEROFF , MD , P h D

D EPARTMENT OF P SYCHIATRY

AND B EHAVIORAL M EDICINE

E MORY U NIVERSITY S CHOOL OF M EDICINE

A TLANTA , GA

M ICHAEL J. H OLTZMAN , MD

D IVISION OF P ULMONARY

AND C RITICAL C ARE M EDICINE

S T . L OUIS , MO

J AMES C. R EYNOLDS , MD

D IVISION OF G ASTROENTEROLOGY

AND H EPATOLOGY

A LLEGHENY U NIVERSITY

OF THE H EALTH S CIENCES

P HILADELPHIA , PA

E THYLIN W ANG J ABS , MD

C ENTER FOR M EDICAL G ENETICS

J OHNS H OPKINS U NIVERSITY S CHOOL

OF M EDICINE

B ALTIMORE , MD

A NTHONY R OSENZWEIG , MD

C ARDIAC U NIT AND C ARDIOVASCULAR

R ESEARCH I NSTITUTE

M ASSACHUSETTS G ENERAL H OSPITAL

B OSTON , MA

L AURENCE K EDES , MD

I NSTITUTE FOR G ENETIC M EDICINE

AND P ROGRAM FOR G ENE T HERAPY

U NIVERSITY OF S OUTHERN C ALIFORNIA

S CHOOL OF M EDICINE

L OS A NGELES , CA

S WEE L AY T HEIN , MRCP , FRCP ath

MRC M OLECULAR H AEMATOLOGY U NIT

I NSTITUTE OF M OLECULAR M EDICINE

J OHN R ADCLIFF H OSPITAL , H EADINGTON

O XFORD , UK

T HOMAS S. K UPPER , MD

D ERMATOLOGY D IVISION

B RIGHAM AND W OMEN ’ S H OSPITAL

B OSTON , MA

R ALPH C. W ILLIAMS , J R ., MD

D IVISION OF R HEUMATOLOGY

D EPARTMENT OF M EDICINE

U NIVERSITY OF F LORIDA

G AINESVILLE , FL

J OSEPH B. M ARTIN , MD , P h D

F ACULTY OF M EDICINE

H ARVARD M EDICAL S CHOOL

B OSTON , MA

CONTENTS

iii

M OLECULAR

M EDICINE

E DITED BY

J. L ARRY J AMESON , MD , P h D

N ORTHWESTERN U NIVERSITY M EDICAL S CHOOL

C HICAGO , IL

F OREWORD BY

F RANCIS S. C OLLINS , MD , P h D

N ATIONAL H UMAN G ENOME R ESEARCH I NSTITUTE

B ETHESDA , MD

H UMANA P RESS

T OTOWA , N EW J ERSEY

P RINCIPLES OF

CONTENTS

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Library of Congress Cataloging-in-Publication Data

Principles of molecular medicine / edited by J. Larry Jameson

foreword by Francis S. Collins.

p. cm.

Includes index.

ISBN 0-89603-529-8 (alk. paper)

1. Medical genetics. 2. Pathology, Molecular. 3. Molecular biology.

I. Jameson, J. Larry.

[DNLM: 1. Genetics, Medical. 2. Molecular Biology. QZ 50 P9573

1998]

RB155.P695 1998

616'.042—dc21

DNLM/DLC

for Library of Congress

98-17729

CIP

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